abstract：:Papillary renal cell carcinoma (PRCC) is currently divided in 2 subtypes. We reviewed a large cohort of PRCC and correlated subtype, morphological features and diagnostic marker expression with overall survival (OS) to uncover differences between the 2 subtypes. Three hundred seventy-six renal tumors initially diagnos...

journal_title：Human pathology

authors： Polifka I,Agaimy A,Herrmann E,Spath V,Trojan L,Stöckle M,Becker F,Ströbel P,Wülfing C,Schrader AJ,Barth P,Staehler M,Stief C,Hohenfellner M,Macher-Göppinger S,Wullich B,Noldus J,Brenner W,Roos FC,Walter B,Otto W,

更新日期：2019-01-01 00:00:00

abstract：:Ovarian ependymomas are rare glial neoplasms that typically occur in women on their third to fourth decades of life. They are histologically similar to ependymomas of the central nervous system but may have a broader immunophenotype. We describe a 27-year-old woman who presented to the emergency department with a 3-we...

journal_title：Human pathology

authors： Lopez LV,Bhattacharyya S,Carlsen ED,Bartlett D,Rao UNM

更新日期：2019-01-01 00:00:00

abstract：:Previous studies have proven that the lepidic component of lung adenocarcinoma is an independent prognostic factor and has a favorable effect on patient prognosis; however, no studies have reported the specific distribution of the lepidic component in lung cancer. In this study, we focused mainly on whether the lepidi...

journal_title：Human pathology

authors： Bian T,Jiang D,Feng J,Liu J,Qian L,Zhang Q,Li X,Liu Y,Zhang J

更新日期：2019-01-01 00:00:00

abstract：:Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...

journal_title：Human pathology

authors： Guilmette J,Dias-Santagata D,Nosé V,Lennerz JK,Sadow PM

更新日期：2019-01-01 00:00:00

abstract：:Renomedullary interstitial cell tumors (RMICTs) are almost always incidentally identified either at autopsy or upon resection of the kidney for other reasons. However, rare cases that are large, resulting in a clinical mass, have been reported. The immunohistochemical phenotype of usual, incidental RMICT using modern ...

journal_title：Human pathology

authors： Lu Z,Al-Obaidy K,Cheng L,Perry KD,Grignon DJ,Williamson SR

更新日期：2018-12-01 00:00:00

abstract：:The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...

journal_title：Human pathology

authors： Johnson DN,Sadow PM

更新日期：2018-12-01 00:00:00

abstract：:NLRC3 is a member of the nucleotide-binding domain and leucine-rich repeat (NLR) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, NLRC3 expression correlation with the development and prognosis of hepatocellular carcinoma (HCC) is...

journal_title：Human pathology

authors： Ma YY,Zhang GH,Li J,Wang SB,Hu ZM,Zhang CW,Li E

更新日期：2018-12-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) plays an important role in invasion and metastasis of various cancers including gliomas. EMT has also been linked to cancer stem cells and resistance to chemotherapy. An initial in-silico data mining in a published ependymoma (EPN) patient series (GSE21687) revealed up-regula...

journal_title：Human pathology

authors： Malgulwar PB,Nambirajan A,Pathak P,Rajeshwari M,Suri V,Sarkar C,Singh M,Sharma MC

更新日期：2018-12-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end-stage renal disease in children and young adults. Approximately 60% of patients with a known genetic etiology of nephronophthisis are due to homozygous deletion of the NPHP1 gene. We identified a total o...

journal_title：Human pathology

authors： Larsen CP,Bonsib SM,Beggs ML,Wilson JD

更新日期：2018-11-01 00:00:00

abstract：:Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma (HCC) with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated HCCs. In the current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immu...

journal_title：Human pathology

authors： Zhao CL,Hui Y,Wang LJ,Yang D,Yakirevich E,Mangray S,Huang CK,Lu S

更新日期：2018-10-01 00:00:00

abstract：:Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) are rare primary glioneuronal tumors that comprise 0.5% to 1.0% of all intracranial tumors. While BRAF mutation is found in up to 50% of pediatric gangliogliomas, data for DIA/DIGs is limited. This study was carried out to evaluate the frequency of BRAF V600E ...

journal_title：Human pathology

authors： Chatterjee D,Garg C,Singla N,Radotra BD

更新日期：2018-10-01 00:00:00

abstract：:In this study, we aimed to identify whether tumor budding is associated with the progression and prognosis of oral squamous cell carcinoma (OSCC) and investigate the correlation between tumor budding and regulators of epithelial-mesenchymal transition (EMT). Fifty-six cases of OSCC were selected and their tumor buddin...

journal_title：Human pathology

authors： Hong KO,Oh KY,Shin WJ,Yoon HJ,Lee JI,Hong SD

更新日期：2018-10-01 00:00:00

abstract：:Literature on BRCA1-associated protein 1 (BAP1) expression status in well-differentiated papillary mesothelioma (WDPM) is limited. In the present study, we examined the prevalence of BAP1 loss in WDPM by immunohistochemistry with clinical correlation, along with CDKN2A deletion status by fluorescence in situ hybridiza...

journal_title：Human pathology

authors： Lee HE,Molina JR,Sukov WR,Roden AC,Yi ES

更新日期：2018-09-01 00:00:00

abstract：:Limitations in obtaining surgically resected or biopsy samples of small cell lung cancer (SCLC) tumors make comprehensive biological analyses difficult. The loss of thyroid transcription factor 1 (TTF-1) has been associated with the aggressive behavior of non-small cell lung cancer; however, clinicopathological featur...

journal_title：Human pathology

authors： Iida Y,Masuda S,Nakanishi Y,Shimizu T,Nishimaki H,Takahashi M,Hikichi M,Maruoka S,Gon Y,Takahashi N,Hashimoto S

更新日期：2018-09-01 00:00:00

abstract：:To investigate the expression and clinical significance of long noncoding RNA (lncRNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein-coding genes and lncRNAs in tumor and paired adjacent nontumor tissues. We found that 41 lncRNAs were up-regulated and 31 lncRNAs were down-r...

journal_title：Human pathology

authors： Li L,Wang YY,Mou XZ,Ye ZY,Zhao ZS

更新日期：2018-08-01 00:00:00

abstract：:Among women in Taiwan, thyroid cancer is the fifth most common malignant neoplasia. However, genomic profiling of papillary thyroid cancer (PTC) cases from Taiwan has not been attempted previously. We used whole-exome sequencing to identify mutations in a cohort of 19 PTC patients. Sequencing was performed using the I...

journal_title：Human pathology

authors： Chang CC,Chang YS,Huang HY,Yeh KT,Liu TC,Chang JG

更新日期：2018-08-01 00:00:00

abstract：:Multicentric Castleman disease (MCD) is a systemic inflammatory disease potentially caused by an increase in the serum interleukin-6 (IL-6) level. Idiopathic MCD (iMCD) is histopathologically classified into three types: plasmacytic (PC), mixed, and hypervascular (hyperV) types. Recently, a unique clinical phenotype w...

journal_title：Human pathology

authors： Kurose N,Futatsuya C,Mizutani KI,Kumagai M,Shioya A,Guo X,Aikawa A,Nakada S,Fujimoto S,Kawabata H,Masaki Y,Takai K,Aoki S,Kojima M,Nakamura S,Yamada S

更新日期：2018-07-01 00:00:00

abstract：:Molecular apocrine breast cancer (MABC) is a molecular subtype with a poor prognosis, and there is urgent need to find new therapeutic targets. Epidermal growth factor receptor (EGFR) plays an important part in regulating the biological behavior of tumor cells, and EGFR-targeted drugs have already been used in therapy...

journal_title：Human pathology

authors： Liu X,Feng C,Liu J,Liu J,Li C,Xu C,Niu Y

更新日期：2018-07-01 00:00:00

abstract：:As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. The aims of this study were to detect BCAT1 expression in GC an...

journal_title：Human pathology

authors： Xu Y,Yu W,Yang T,Zhang M,Liang C,Cai X,Shao Q

更新日期：2018-05-01 00:00:00

abstract：:The Renal Pathology Society proposed a pathological classification for diabetic nephropathy (DN) (RPS 2010). We retrospectively examined the renal structural-functional relationships using the RPS 2010 classification in 49 DN cases. We also evaluated the importance of the percentage of glomeruli with nodular diabetic ...

journal_title：Human pathology

authors： Yasuda F,Mii A,Morita M,Aoki M,Tagawa M,Aratani S,Kaneko T,Sakai Y,Shimizu A

更新日期：2018-05-01 00:00:00

abstract：:Gastric heterotopia of the intestinal tract can have a diverse clinicopathologic presentation, resulting in a diagnostic dilemma. We present a series of four cases, two male and two female patients with age range of 31-82 years, found in the duodenum, jejunum, and transverse colon. The most common and rather unusual c...

journal_title：Human pathology

authors： Nasir A,Amateau SK,Khan S,Simpson RW,Snover DC,Amin K

更新日期：2018-04-01 00:00:00

abstract：:AT-rich interaction domain 4B (ARID4B), which belongs to the ARID family, is heavily involved in cell growth and differentiation and is closely associated with many types of tumors. However, the role of this protein in hepatocellular carcinoma (HCC) remains unknown. In this study, we used data from The Cancer Genome A...

journal_title：Human pathology

authors： Wang R,Yu Z,Chen F,Liao C,Wang Q,Huang X

更新日期：2018-03-01 00:00:00

abstract：:We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose of determining and correlating a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was composed of 720 men and 750...

journal_title：Human pathology

authors： Weissferdt A,Kalhor N,Bishop JA,Jang SJ,Ro J,Petersson F,Wu B,Langman G,Bancroft H,Bi Y,Meng Y,Medeiros F,Brunnstrom H,Spagnolo D,Chai SM,Laycock A,Wakely PE Jr,Elmberger G,Soares FA,Campos AH,Gumurdulu D,Alvara

更新日期：2018-03-01 00:00:00

abstract：:Primary carcinomas of the urethra are rare and poorly understood lesions; hence, their clinical and pathologic spectrum is not completely defined. We analyzed a series of 130 primary urethral tumors and classified 106 of them as primary urethral carcinomas. The age at diagnosis of patients with primary urethral carcin...

journal_title：Human pathology

authors： Zhang M,Adeniran AJ,Vikram R,Tamboli P,Pettaway C,Bondaruk J,Liu J,Baggerly K,Czerniak B

更新日期：2018-02-01 00:00:00

abstract：:The histone methyltransferase G9a (EHMT2) is a key enzyme for dimethylation of lysine 9 at histone 3 (H3K9me2), a suppressive epigenetic mark. G9a is over-expressed in tumor cells and contributes to cancer aggressiveness. Biliary tract cancer (BTC) is a rare cancer with dismal prognosis due to a lack of effective ther...

journal_title：Human pathology

authors： Mayr C,Helm K,Jakab M,Ritter M,Shrestha R,Makaju R,Wagner A,Pichler M,Beyreis M,Staettner S,Jaeger T,Klieser E,Kiesslich T,Neureiter D

更新日期：2018-02-01 00:00:00

abstract：:Monoclonal antibodies to somatostatin receptors 2A (SSTR2A, UMB-1) and 5 (SSTR5, UMB-4) were reported to be highly reliable for immunohistochemical detection of these receptors in neuroendocrine neoplasms. However, the standardization of either the immunohistochemical procedure and the methods of evaluation has yet to...

journal_title：Human pathology

authors： Kasajima A,Papotti M,Ito W,Brizzi MP,La Salvia A,Rapa I,Tachibana T,Yazdani S,Sasano H,Volante M

更新日期：2018-02-01 00:00:00

abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...

journal_title：Human pathology

authors： Xing D,Banet N,Sharma R,Vang R,Ronnett BM,Illei PB

更新日期：2018-02-01 00:00:00

abstract：:Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridiza...

journal_title：Human pathology

authors： Pradhan D,Schoedel K,McGough RL,Ranganathan S,Rao UNM

更新日期：2018-01-01 00:00:00

abstract：:Primary renal collision tumors composed of 2 histologically distinct components are rare with only isolated case reports in the medical literature. Oncocytoma is a benign renal neoplasm, which is thought to originate from distal tubular epithelial cells. Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is...

journal_title：Human pathology

authors： Arora K,Miller R,Mullick S,Shen S,Ayala AG,Ro JY

更新日期：2018-01-01 00:00:00

abstract：:Recently, we reported 2 mixed endometrioid endometrial carcinomas with a "low-grade serous"-like component, which does not fit into any of the 4 molecular groups described by The Cancer Genome Atlas. To understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these 2 ca...

journal_title：Human pathology

authors： Espinosa I,D'Angelo E,Corominas M,Gonzalez A,Prat J

更新日期：2018-01-01 00:00:00

abstract：:Germline BRCA mutations account for a significant proportion of genetic/familial risk of breast and ovarian cancer (GBOC) susceptibility, but a broader spectrum of GBOC susceptibility genes has emerged in recent years. Genotype-to-phenotype correlations are known for some established forms of GBOC; however, whether su...

journal_title：Human pathology

authors： Schoolmeester JK,Moyer AM,Goodenberger ML,Keeney GL,Carter JM,Bakkum-Gamez JN

更新日期：2017-12-01 00:00:00

abstract：:SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was established using limited samples and resources. A woman in her early 30s developed...

journal_title：Human pathology

authors： Kuwamoto S,Matsushita M,Takeda K,Tanaka N,Endo Y,Yamasaki A,Kohashi K,Oda Y,Horie Y

更新日期：2017-12-01 00:00:00

abstract：:Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (ht...

journal_title：Human pathology

authors： Zheng Y,Lu X,Xu L,Chen Z,Li Q,Yuan J

更新日期：2017-11-01 00:00:00

abstract：:Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. Although more than 90% of GCTBs present histone 3.3 variants exclusively in the H3F3A gene, chondroblas...

journal_title：Human pathology

authors： Righi A,Mancini I,Gambarotti M,Picci P,Gamberi G,Marraccini C,Dei Tos AP,Simi L,Pinzani P,Franchi A

更新日期：2017-10-01 00:00:00

abstract：:The use of prosthetic implants for breast augmentation has become commonplace. Although implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report 2 cases of breast implant capsule-associated squamous cell carcinoma with poor clinical ...

journal_title：Human pathology

authors： Olsen DL,Keeney GL,Chen B,Visscher DW,Carter JM

更新日期：2017-09-01 00:00:00

abstract：:Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime. Prediction of transformation, typically from plexiform neurofibroma, is clinically and histologically challenging. In this overview, aft...

journal_title：Human pathology

authors： Miettinen MM,Antonescu CR,Fletcher CDM,Kim A,Lazar AJ,Quezado MM,Reilly KM,Stemmer-Rachamimov A,Stewart DR,Viskochil D,Widemann B,Perry A

更新日期：2017-09-01 00:00:00

abstract：:The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging because of significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32...

journal_title：Human pathology

authors： Giannico GA,Gown AM,Epstein JI,Revetta F,Bishop JA

更新日期：2017-09-01 00:00:00

abstract：:p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It ...

journal_title：Human pathology

authors： Liu Y,Alqatari M,Sultan K,Ye F,Gao D,Sigel K,Zhang D,Kalir T

更新日期：2017-08-01 00:00:00

abstract：:FoxA1 regulates a variety of tissues during embryogenesis and early life. In thyroid, FoxA1 expression has recently been shown in C cells and medullary thyroid carcinomas but not in follicular cells. FoxA1 has also been proposed as a potential oncogene in anaplastic thyroid carcinomas. However, FoxA1 expression has no...

journal_title：Human pathology

authors： Nonaka D

更新日期：2017-07-01 00:00:00

abstract：:Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance. Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin compaction, leading to inaccessibility of promoter regions and eventually gene silencing. Many cancer entities feature overexpression of HDACs. Cu...

journal_title：Human pathology

authors： Klieser E,Urbas R,Stättner S,Primavesi F,Jäger T,Dinnewitzer A,Mayr C,Kiesslich T,Holzmann K,Di Fazio P,Neureiter D,Swierczynski S

更新日期：2017-07-01 00:00:00